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张小蕾 Xiaolei Zhang

I am passionate about advancing healthcare using computational and statistical approaches. I have studied Computational Biology and Bioinformatics in ETH Zurich. I am finishing my PhD in Imperial College London in the study of statistical methods for clinical genome interpretation with specific application in inherited cardiac conditions.

Publications

X Zhang et al. Disease-specific variant pathogenicity prediction significantly improves clinical variant interpretation in inherited cardiac conditions (In preparation) [CardioBoost]

6. N Whiffin, KJ Karczewski, X Zhang, S Chothani, et al. Characterising the loss-of-function impact of 5' untranslated region variants in whole genome sequence data from 15,708 individuals. Nature Communications (To appear) [DOI] [Code]

5. M Maiolo, X Zhang, M Gil, M Anisimova. Progressive multiple sequence alignment With indel evolution. BMC bioinformatics [DOI]

4. R Yao, M Heinrich,Y Zou, E Reich, X Zhang, Y Chen, CS Weckerle. Quality Variation of Goji (Fruits of Lycium spp.) in China: A Comparative Morphological and Metabolomic Analysis. Frontiers in pharmacology [DOI]

3. N Whiffin, R Walsh, R Govind, M Edwards, M Ahmad, X Zhang et al. CardioClassifier: disease- and gene-specific computational decision support for clinical genome interpretation.Genetics In Medicine [DOI]

2. X Zhang, E Minikel, A O’Donnell-Luria, D MacArthur, J Ware, B Weisburd. ClinVar Data Parsing . Wellcome Open Research [DOI][Code]

1. Y Dong, X Zhang*, M Xie, B Arefnezhad et al. Reference genome of wild goat (capra aegagrus) and sequencing of goat breeds provide insight into genic basis of goat domestication. BMC genomics [DOI] (* co-first author)

Projects

Here is a collection of some interesting projects I've worked on

(I like this cool website)