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张小蕾 Xiaolei Zhang

I am passionate about advancing healthcare using computational and statistical approaches. I have studied Computational Biology and Bioinformatics in ETH Zurich. I am finishing my PhD in Imperial College London in the study of statistical methods for clinical genome interpretation with specific application in inherited cardiac conditions.


9. X Zhang, M Wakeling, J Ware, N Whiffin Annotating high-impact 5’untranslated region variants with the UTRannotator Bioinformatics [DOI] [UTRannotator]

8. X Zhang et al. Disease-specific variant pathogenicity prediction significantly improves clinical variant interpretation in inherited cardiac conditions. Genetics in Medicine [DOI] [CardioBoost]

7. N Whiffin, KJ Karczewski, X Zhang, S Chothani, et al. Characterising the loss-of-function impact of 5' untranslated region variants in whole genome sequence data from 15,708 individuals. Nature Communications [DOI] [Code]

6. R Yao, M Heinrich,Y Zou, E Reich, X Zhang, Y Chen, CS Weckerle. Quality Variation of Goji (Fruits of Lycium spp.) in China: A Comparative Morphological and Metabolomic Analysis. Frontiers in pharmacology [DOI]

5. N Whiffin, R Walsh, R Govind, M Edwards, M Ahmad, X Zhang et al. CardioClassifier: disease- and gene-specific computational decision support for clinical genome interpretation.Genetics In Medicine [DOI]

4. X Zhang, E Minikel, A O’Donnell-Luria, D MacArthur, J Ware, B Weisburd. ClinVar Data Parsing . Wellcome Open Research [DOI][Code]

3. M Maiolo, X Zhang, M Gil, M Anisimova. Progressive multiple sequence alignment With indel evolution. BMC bioinformatics [DOI]

2. X Zhang Analysis of Bias and Reliability of Progressive Poisson Indel Process Algorithm. Master Thesis, ETH Zurich. [PDF]

1. Y Dong, X Zhang*, M Xie, B Arefnezhad et al. Reference genome of wild goat (capra aegagrus) and sequencing of goat breeds provide insight into genic basis of goat domestication. BMC genomics [DOI] (* co-first author)


Here is a collection of some interesting projects I've worked on

(I like this minimalist website)